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Updated: Jul 11, 2025

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RNF2通过TCF7L1破坏稳定来调节Wnt/β-catenin信号传输

Youngmu Koo1, Wonhee Han2, Byeong-Rak Keum1

  • 1Department of Life Sciences, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Republic of Korea.

Scientific reports
|November 13, 2023
PubMed
概括

E3酶RNF2通过准TCF7L1进行降解来积极调节Wnt路径. RNF2通过破坏TCF7L1.1.的稳定性来控制Wnt信号的动态,包括它的值,持久性和终止性.

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