在治疗非结核性菌根性肺病期间液微生物群的变化
Bo-Guen Kim1, Jin Young Yu2, Su-Young Kim3
1Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Scientific reports
|November 13, 2023
概括
在非结核性菌根性肺病 (NTM-PD) 的抗生素治疗期间,唾液中的细菌多样性会减少. 响应性患者显示微生物种群的减少,而耐火性患者显示特定细菌的增加,如Pseudomonas aeruginosa.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 遗传学 遗传学 是一个
背景情况:
- 非结核性菌根性肺病 (NTM-PD) 的治疗具有挑战性,对纵向微生物组变化的理解有限.
- 细菌菌微生物组在NTM-PD治疗反应中的作用在很大程度上仍未被探索.
研究的目的:
- 在NTM-PD的抗生素治疗期间,研究液细菌微生物群的纵向变化.
- 为了比较实现培养转换的患者和耐火性疾病患者之间的微生物组动态.
主要方法:
- 在治疗12个月期间,从14名NTM-PD患者收集连续唾液样本的前景采集.
- 16S rRNA基因测序 (V3-V4区域) 用于分析细菌微生物组的组成和多样性.
- 亚组分析比较培养转换和耐火组,使用α-多样性,β-多样性和LEfSe.
主要成果:
- 在治疗期间,液α-多样性在所有患者中显著下降.
- 培养转换组显示出显著的β-多样性变化和总体的税率下降.
- 耐火组没有显著的β-多样性变化,而Veillonella dispar,Fusobacterium periodonticum和Pseudomonas aeruginosa的显着增加.
结论:
- 在NTM-PD治疗期间,液微生物群的多样性下降.
- 响应性NTM-PD患者显示大多数细菌种群的减少,而耐火患者显示特定机会性病原体的增加.
- 独特的呼吸道微生物群落可能是耐火性NTM-PD的特征,影响治疗结果.
相关概念视频
01:26Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture
210
Sputum studies are a critical part of diagnosing and treating numerous respiratory conditions. These studies involve obtaining sputum samples for analysis to identify pathogenic organisms and assess the presence of abnormal cells indicative of malignant conditions. This lesson will delve into three fundamental sputum studies: Gram Stain, Cytology, and Acid-fast Smear and Culture.
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
210
01:28Pulmonary Tuberculosis V
183
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
183
01:20Sputum Studies II: Culture and Sensitivity
357
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
357
01:28Pulmonary Tuberculosis II
243
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
243
01:26Pulmonary Tuberculosis IV
144
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
144
01:29Pulmonary Tuberculosis I
246
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
246