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Updated: Jul 11, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

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诱导的替代拼接为研究生理学相关度的PCSK9蛋白质异型提供了机会

Jessica M Cale1, Kristin A Ham1,2, Dunhui Li1,2

  • 1Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.

Scientific reports
|November 13, 2023
PubMed
概括

用于研究9型 (PCSK9) 蛋白质异型的proprotein转化酶亚素/kexin类型 (PCSK9) 蛋白质异型,使用了反感性寡合体 (AO). 针对特定的PCSK9区域可能通过调节LDL受体活性来为高胆固醇血症提供治疗潜力.

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