在家族地中海热病患者中出现焦虑和抑郁症
Ozgur C Kilinc1, Abdulmenaf Kilinc1, Feyza N Azman1
1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 53 Kocamustafapasa Street, Fatih, 34098, Istanbul, Turkey.
Zeitschrift fur Rheumatologie
|November 13, 2023
概括
家庭地中海热 (FMF) 患者经历了轻度抑郁和中度焦虑. 高等教育和药物坚持与FMF患者的焦虑水平较低相关.
科学领域:
- 医学研究 医学研究
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 家庭地中海热 (FMF) 是一种慢性自身炎症性疾病.
- FMF与并发症有关,包括焦虑和抑郁症.
- 需要进一步研究FMF和心理健康影响.
研究的目的:
- 为了调查FMF患者的焦虑和抑郁水平.
- 探索心理健康与FMF各种因素之间的关系.
- 评估基因突变和治疗坚持对心理健康结果的影响.
主要方法:
- 在2022年6月至10月期间调查了360名FMF患者.
- 使用了贝克的抑郁症清单 (BDI) 和贝克的焦虑清单 (BAI).
- 为了评估焦虑,他们使用了州道焦虑清单 (STAI).
主要成果:
- FMF患者呈现出轻度抑郁 (BDI:13.1±8.99) 和中度焦虑 (STAI-Y1:42.2±12.0; STAI-Y2:45.9±10.6; BAI:24.0±13.9).这些患者的症状包括:
- 药物坚持与较低状态焦虑 (STAI-Y1) 有关.
- 与其他类型相比,特定的基因型 (M694V同卵性,exon-10突变) 显示抑郁和焦虑得分明显较低.
结论:
- FMF患者表现出轻度抑郁和中度焦虑.
- 高等教育和一致的药物坚持与减少焦虑有关.
- 与严重的FMF疗程相关的基因型与较低的焦虑水平相关,因此需要对患有较轻症的患者给予临床关注.
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