在OIT期间,与乙氨基相关的胃肠道表现.
Michael R Goldberg1,2, Naama Epstein-Rigbi3,4, Arnon Elizur3,4
1Institute of Allergy, Immunology and Pediatric Pulmonology, Yitzhak Shamir Medical Center (Assaf Harofeh), Zerifin, 70300, Israel. goldbergsm@yahoo.com.
Clinical reviews in allergy & immunology
|November 13, 2023
概括
对食物过敏的口服免疫疗法 (OIT) 可以导致胃肠道问题. 本综述详细介绍了OIT期间发生的两种类型的非亚纳菲拉克斯性氨基酸相关的胃肠道事件,指导了它们的独特管理策略.
科学领域:
- 胃肠病学 胃肠病学
- 过敏和免疫学 过敏和免疫学
- 临床治疗学 临床治疗学
背景情况:
- 在食物过敏的口服免疫疗法 (OIT) 期间,胃肠道不良事件很常见.
- 这些事件的范围从直接的IgE介导反应到非过敏反应的呈现.
- 本综述重点关注OIT期间与乙氨基酸相关的非过敏性胃肠道不良事件.
研究的目的:
- 总结最近在OIT期间对非亚纳菲拉克斯型乙酸酶相关的胃肠道不良事件的发现.
- 根据发病和治疗来区分两个临床表现.
- 确定这些事件的风险因素和管理策略.
主要方法:
- 对OIT诱导的胃肠道不良事件的最新文献的综述.
- 识别和分类非亚纳菲拉克斯性异osinophil相关事件.
- 对临床表现,生物标志物和治疗反应的分析.
主要成果:
- 鉴定出了两个不同临床表现的非亚纳菲拉克斯性埃索因菲尔相关的胃肠道不良事件.
- 早期发病的事件 (几周到几个月) 涉及腹痛,恶心,吐和潜在的绝对乙酸细胞数 (AEC) 增加,通过剂量调整来控制.
- 晚期发作的事件 (几个月到几年) 呈现为乙酸性食道炎 (EoE),用标准的EoE疗法治疗.
结论:
- 在OIT期间,非亚纳菲拉克斯型乙氨基基酸相关的胃肠道不良事件具有明显的早期和晚期表现.
- 根据临床表现和发病情况,管理策略有所不同.
- 大多数患者可以通过适当管理这些不良事件继续进行OIT.
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