在口腔可分散膜中未满足的技术需求,用于适合儿童年龄的儿科药物输送
Indhu Annie Chacko1, Gayathri Ramachandran1, M S Sudheesh2
1Department of Pharmaceutics, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, 682041, Ponekkara, Kochi, India.
Drug delivery and translational research
|November 13, 2023
概括
开发适合儿童年龄的配方对于安全的药物输送和药物遵守至关重要. 口腔可分散膜 (ODF) 在解决儿科药物输送方面的挑战方面表现有前途,改善了患者接受度.
科学领域:
- 制药科学 制药科学
- 儿科药物输送 儿科药物输送
- 制定 发展 制定 发展
背景情况:
- 儿科药物输送面临重大挑战,包括未知的辅助剂安全性,缺乏适合年龄的配方,口味掩盖不良,药物动力学数据有限.
- 确保适应年龄对于改善医疗遵守和减少儿童药物错误至关重要.
- 根据年龄预测儿科配方的生物制药性能仍然是一个未满足的需求.
研究的目的:
- 审查开发适合年龄的儿科配方所面临的挑战和潜在的解决方案.
- 探索口腔可分散膜 (ODF) 的作用,作为一个有希望的适合儿童年龄的配方技术,用于儿科药物输送.
- 讨论技术进步,可以提高儿童患者接受和有效的ODF.
主要方法:
- 审查当前关于儿科药物输送挑战的文献.
- 分析口腔可分散膜 (ODF) 技术及其在儿科的潜在应用.
- 讨论技术改进,如口味掩饰,可溶性增强和用于ODF制备的3D打印.
主要成果:
- 口腔可分散膜 (ODF) 被认为是适合儿童年龄的药物输送的有希望的技术.
- 在口味掩饰,药物溶解性,溶解率和灵活剂量的技术进步提高了ODF的适用性.
- 在良好制造实践 (GMP) 环境中的3D打印提供了ODF的定制和即时准备.
结论:
- 开放式塑料制剂技术提供了一种可行的解决方案,以解决儿童医学中对年龄适当配方的关键需求.
- 在ODF技术的改进可以显著提高儿童群体的患者接受和医疗坚持.
- 进一步开发和实施ODF,特别是3D打印,对于推进儿科药物输送具有巨大潜力.
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