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与慢性病相关的视网膜变化和心脏生物标志物评估:单一中心研究
Ruslinda Mustafar1, Khairun Amalin Mohd Hishamuddin2, Rozita Mohd1
1Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
BMC nephrology
|November 14, 2023
概括
马来西亚的慢性病 (CKD) 正在上升. 视网膜血管变化和hs-CRP等心脏生物标志物与CKD进展相关,提供潜在的非侵入性评估工具. 斑点体积可能表明CKD患者的心血管风险.
科学领域:
- 眼科和科的眼科和科.
- 生物标志物发现发现
- 心血管风险分层的分层.
背景情况:
- 马来西亚慢性病 (CKD) 的患病率不断上升,需要及早检测以减轻心血管 (CV) 风险,这是末期病 (ESRD) 的主要死亡原因.
- 视网膜变化是CKD的指标,而心脏生物标志物有助于评估心血管风险.
- 这项研究调查了视网膜变化,心脏生物标志物和CKD之间的关系.
研究的目的:
- 探索慢性病 (CKD) 不同阶段患者的特定视网膜成像参数和心脏生物标志物之间的相关性.
- 评估这些参数作为CKD评估和心血管风险分层的非侵入性标记物的潜力.
主要方法:
- 一个单一中心的横截面研究,涉及84名患有CKD 3-5期 (非透析) 的患者.
- 底部摄影被用来分析视网膜血管口径 (CRVE,CRAE) 和扭曲度.
- 光学连贯断层扫描测量了黄斑体积,而血液样本评估了hs-CRP和ADMA水平.
主要成果:
- 视网膜血管扭曲和中央视网膜静脉等效 (CRVE) 与估计的球透率 (eGFR) 和蛋白尿有显著的相关性.
- 高灵敏度C反应蛋白 (hs-CRP) 水平与EGFR负相关,与蛋白尿相关.
- 糖尿病患者表现出更高的CRVE,而缺血性心脏病史与较小的斑点体积有关. 年龄,男性性别,HbA1c和hs-CRP影响了视网膜参数.
结论:
- eGFR是影响视网膜血管曲,CRVE和hs-CRP的重要因素,表明它们作为非侵入性CKD评估工具的实用性.
- 斑点体积似乎是与CKD人口中心血管风险相关的主要参数.
- 需要进一步的研究来验证这些发现及其在治疗慢性病患者中的临床适用性.
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