青少年皮肤肌炎:指甲毛细血管末 row loop- 曲线下面的区域和疾病损伤指标之间的关联
Amer Khojah1,2, Gabrielle Morgan2, Marisa S Klein-Gitelman2,3
1Department of Pediatrics, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Pediatric rheumatology online journal
|November 14, 2023
概括
在青少年皮肤肌炎 (JDM) 中持续低的指甲毛细血管末排环 (ERL) 与慢性疾病和脂质变相关. 即使经过五年的治疗,许多JDM患者的ERL密度仍然低于正常水平.
科学领域:
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
- 皮肤病学 皮肤病学
背景情况:
- 青少年皮肤肌炎 (JDM) 是一种罕见的自身免疫性疾病,导致皮肤和肌肉炎症.
- 爪毛细血管末排环 (ERL) 的损失表明JDM中的小血管损伤.
- 这项研究调查了整个JDM过程中RL变化和疾病损伤之间的联系.
研究的目的:
- 检查随时间推移的RLR密度与JDM疾病进展和损伤的关联.
- 评估RL毛细血管密度是否与特定的JDM疾病过程和并发症相关.
主要方法:
- 分析了68名从未接受过治疗的JDM儿童的数据,这些儿童被跟踪了五年多.
- 使用曲线下的面积 (AUC) 方法对 ERL 密度的多重评估.
- 将JDM疾病过程分类为单环短,单环长,多环和慢性.
主要成果:
- 在JDM患者中,平均ERL密度明显低于健康对照组 (4.8±1.6毫米对比7.9±0.9毫米).
- 与单环短期和长期疗程相比,慢性JDM病例中观察到较低的ERL AUC.
- 患有脂质缩症的JDM患者的ERL AUC显著低于没有的患者.
结论:
- 持续下降的RLR毛细血管密度 (低RLR AUC) 与慢性JDM和脂质变有关.
- 至少五年来,RLR数量一直低于正常水平,特别是在慢性和多循环的JDM中.
- 在JDM患者中恢复正常的毛细血管密度,目前可能无法通过现有疗法实现.
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