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血液病患者在医院定居的万科米辛耐药肠球菌风险因素:一个匹配的病例对照研究

Marianna Meschiari¹, Shaniko Kaleci², Martina Del Monte³

¹Department of Infectious Diseases, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Via del Pozzo 71, Modena, 41122, Italy. mariannameschiari1209@gmail.com.

Antimicrobial resistance and infection control

|November 14, 2023

概括

在血液病患者中,抗万科明素肠 (VRE) 的直肠定居与万科明素使用和改变肠道习惯有关. VRE殖民并没有影响死亡率,但与Clostridioides difficile感染相关.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
临床微生物学临床微生物学

背景情况:

抗菌素的肠球菌 (VRE) 是欧洲快速增长的病原体.
在血液病患者中VRE定居的临床相关性仍然不清楚.
确定VRE殖民的风险因素和临床影响至关重要.

研究的目的:

为了确定血液病患者获得的VRE直肠定居的危险因素.
评估VRE殖民对后续感染的临床影响.
评估VRE殖民对30日和90日死亡率的影响.

主要方法:

追溯,单中心,病例控制匹配研究 (1:1比率).
血液学患者查VRE直肠定植 (≥48h).
用于识别风险因素的单变量和多变量逻辑回归.

主要成果:

83个病例与83个对照进行了匹配.
对VRE定居的独立风险因素是万科米辛的使用和改变的肠道习惯.
VRE细菌病和Clostridioides difficile感染 (CDI) 在病例中更为频繁,但30日和90日死亡率没有受到影响.

结论:

需要进行抗微生物药物管理,以减少格拉姆阳性病例的覆盖率.
范科米辛的使用和改变肠道习惯是VRE殖民的独立风险因素.
需要进一步调查CDI和VRE之间的相关性.

关键词:

血液学上的血液学.风险因素风险因素抗万科胺素的恩特洛科克菌.

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