对耐火性慢性咳和无法解释的慢性咳的新见解:一项为期6年的两向性队列研究
Mengru Zhang1,2, Alyn H Morice3, Fengli Si1
1Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Allergy, asthma & immunology research
|November 14, 2023
概括
耐药性慢性咳 (RCC) 和无法解释的慢性咳 (UCC) 管理在三分之二的患者中改善了症状. 咳持续时间长,对说话或冷空气敏感,表明慢性咳患者的治疗失败.
科学领域:
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
背景情况:
- 耐火性慢性咳 (RCC) 和无法解释的慢性咳 (UCC) 存在独特的临床挑战.
- 有限的研究详细介绍了RCC和UCC的特征和管理.
研究的目的:
- 描述一大群RCC/UCC患者的人口特征,临床表现和长期结果.
- 为管理RCC和UCC提供现实世界,指导性临床经验.
主要方法:
- 来自临床研究数据库的基线数据的回顾性分析 (2016年1月 - 2021年5月).
- 在最后一次诊所访问后至少6个月的时间内对受试者进行前性随访.
主要成果:
- 分析了369名RCC/UCC患者,53.9%是女性,咳的平均持续时间为24个月.
- 喉症状很普遍 (95.9%);常见的触发因素包括说话,气味,饮食和冷空气.
- 耐药性反流性咳占RCC病例的90.8%,并显示出更好的治疗反应 (P < 0.01).
- 总体而言,68.8%的患者报告咳改善或缓解,而RCC显示出更有利的结果 (P <0.01).
- 与较差的结果相关的因素包括咳持续时间长,尿失禁频繁,对说话或冷空气敏感.
结论:
- 目前的治疗方法在约三分之二的慢性咳患者中提供了症状改善.
- 咳持续时间长,对谈话或冷空气等特定触发物的敏感性是潜在治疗失败的指标.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:22Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:23Chronic Pharyngitis
2.4K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.4K
01:20COPD: Pathogenesis and Clinical Features
302
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
302
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.8K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.8K