在动物间传播的衍毒素产生的Corynebacterium ulcerans
Adeline Hillan1, Tristan Gibbs2,3, Graham Weaire-Buchanan2
1Metropolitan Communicable Disease Control, North Metropolitan Health Service, Perth, Western Australia, Australia.
Zoonoses and public health
|November 14, 2023
概括
澳大利亚罕见的白喉病例再次出现,凸显了对Corynebacterium ulcerans的持续公共卫生管理的需要,这是一种可能由物传播的动物性疾病.
科学领域:
- 动物传染性传染病是动物传播的传染病.
- 公共卫生微生物学
- 流行病学 流行病学
背景情况:
- 由产生毒素的Corynebacterium ulcerans引起的白血病是一种重新出现的疾病,具有潜在的局部和全身影响.
- 澳大利亚的高疫苗接种覆盖率使得毒源性白喉病变得罕见,但皮肤C. ulcerans病例的管理在各司法管辖区之间有所不同.
- 对C. ulcerans的公共卫生反应与更常见的Corynebacterium diphtheriae的公共卫生反应不同.
研究的目的:
- 在澳大利亚报告一例动物感染的Corynebacterium ulcerans病例.
- 审查有关C. ulcerans.动物性传染病库和传播事件的证据.
- 检查当前公共卫生指导方针,以管理人类和动物接触C. ulcerans.
主要方法:
- 人类C.病例的详细案例调查,治疗和公共卫生管理.
- 采用了接触追踪和动物试验的系统方法.
- 全基因组测序 (WGS) 用于确认人类病例与动物来源之间的联系.
主要成果:
- 伴侣犬被确定为动物性C.Ulcerans感染的可能来源.
- 世界动物学会证实了人类病例与已识别的犬类来源之间的流行病学联系.
- 已经确立了C. ulcerans与家禽的动物性感染联系,但与动物接触的管理仍然与指导方针不一致.
结论:
- 对于Corynebacterium ulcerans病例,需要采取一致的公共卫生管理方法.
- 系统地阐明疾病来源和更好地了解传播是至关重要的.
- 需要标准化的指导方针来管理人类C.病例中的动物接触.
更多相关视频
11:44Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants
Published on: May 13, 2015
10.0K
10:29Applying Fluorescence Resonance Energy Transfer FRET to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing
Published on: July 6, 2016
10.7K
相关概念视频
01:30Bacterial Phylum Actinobacteria
19
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
19
00:43Lysogenic Cycle of Bacteriophages
62.3K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
62.3K
01:29Pulmonary Tuberculosis I
246
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
246
01:20Infection
8.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.0K
01:28Pulmonary Tuberculosis II
243
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
243
01:30Bacterial Phylum Spirochaetes
18
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
18