在患有右心室节奏的患者中,心室和门功能的演变 - - 一项随机对照试验,比较无和常规节奏
Christophe Garweg1,2, Jürgen Duchenne1, Bert Vandenberk1
1Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Pacing and clinical electrophysiology : PACE
|November 14, 2023
概括
无心脏起器 (Micra) 显示出与传统心脏起器相似的腹腔功能,但三起却较少. 这项研究评估了无节奏技术对心脏的长期影响.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 无心脏起器 (PMs) 是传统起器的替代品,旨在减少与有关的并发症.
- 虽然最初的安全性和有效性很高,但对心脏结构的长期影响需要进一步研究.
研究的目的:
- 为了比较Micra无心脏起器与传统心脏起器对心脏功能的机械影响.
- 为了评估左心室功能,全球纵向应变和门功能在12个月内的差异.
主要方法:
- 一项非劣势性试验随机分配患者接受Micra或传统的单腔心室节奏.
- 心声学评估左心室喷射率 (LVEF) 和全球纵向应变 (GLS) 在基线,6个月和12个月.
- 还分析了三腹的严重程度和N-终端亲激素B型性尿素 (NT-pro-BNP) 水平.
主要成果:
- 左心室功能 (LVEF,GLS) 在12个月后在Micra和传统组中显示出类似的恶化.
- 与常规节奏相比,微节奏导致三管反的严重程度显著降低 (p=0.009).
- 在Micra组 (970 pg/dL) 与传统组 (1394 pg/dL,p=0.041) 相比,中位数NT-pro-BNP水平较低.
结论:
- 在12个月后,Micra在左心室功能演变方面与传统起器无差.
- 麦克拉对心室缩功能表现出类似的机械影响.
- 与传统系统相比,使用Micra的无步行可能会导致减少膜功能障碍.
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