与肥胖相关的气道过敏反应:潜在的炎症标志物的机制和可能的药理干预措施
Manash Pratim Pathak1, Pompy Patowary2, Pronobesh Chattopadhyay2
1Faculty of Pharmaceutical Science, Assam down town University, Guwahati, India.
Endocrine, metabolic & immune disorders drug targets
|November 14, 2023
概括
肥胖会显著加重喘的严重程度,并降低治疗的有效性. 本综述探讨了将肥胖病理与呼吸道过敏反应 (AHR) 联系在一起的复杂机制,以指导更好的喘管理.
科学领域:
- 肺部医学 肺部医学
- 代谢障碍 代谢障碍 代谢障碍
- 免疫学 免疫学 免疫学
背景情况:
- 肥胖是一个全球性的健康危机,全球13%的人口受到影响,特别是妇女和儿童.
- 患有喘的肥胖个体经历了症状严重程度的增加,药物反应较差,生活质量下降.
- 关联肥胖与呼吸道过敏反应 (AHR) 的确切机制仍然不完全理解,尽管公众越来越关注.
研究的目的:
- 审查和关联已知肥胖的病理生理机制,这可能解释其与AHR的关联.
- 突出需要综合治疗策略,解决喘和肥胖症.
- 为 AHR 肥胖患者开发先进的药理干预提供基础.
主要方法:
- 对已发表的报告的文献综述,这些报告将肥胖病理与AHR相关联.
- 分析机制,包括阿迪波金失衡,Nrf2/HO-1轴枯竭,NLRP3炎症酶激活和脂肪组织功能的改变 (WAT,BAT).
- 检查AMPKα和黑色皮质素通路的作用,以及身体质量指数 (BMI) 与腰围 (WC) 对AHR的不同影响.
主要成果:
- 肥胖与增加的促炎和减少的抗炎阿迪波金相关.
- 与肥胖相关的关键路径,如Nrf2/HO-1,NLRP3炎症体和改变的WAT/BAT功能可能会导致AHR.
- 有证据表明,BMI可能比WC更强烈地与过度的气道关闭有关.
结论:
- 了解肥胖引起的炎症,代谢功能障碍和AHR之间的相互作用至关重要.
- 需要综合治疗方法,与传统喘疗法一起针对肥胖病原体.
- 本综述为改善肥胖喘患者的药理干预提供了见解.
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