甲状腺疾病和周围动脉疾病
Katica Bajuk Studen1,2, Simona Gaberscek1,2, Katja Zaletel1,2
1Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Current vascular pharmacology
|November 14, 2023
概括
甲状腺功能障碍,包括甲状腺功能障碍和甲状腺功能障碍,会增加心血管疾病的风险. 研究探讨了甲状腺疾病和外周动脉疾病之间的联系,突出了潜在的机制,如内皮功能障碍和炎症.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 血管生物学 血管生物学
背景情况:
- 甲状腺疾病 (甲状腺功能低下,甲状腺功能过高) 与心血管疾病 (CVD) 风险有关.
- 甲状腺刺激激素 (TSH) 水平显示出与心血管风险的U形关联.
- 连接甲状腺功能和心血管疾病的机制已知,但外围动脉疾病 (PAD) 的并发症需要进一步调查.
研究的目的:
- 在患有甲状腺功能障碍的患者中调查周围动脉疾病 (PAD) 的特定临床并发症.
- 探索将甲状腺功能低下症和甲状腺功能过高症与PAD联系起来的病理生理机制.
主要方法:
- 对甲状腺功能和心血管风险的流行病学研究和元分析的审查.
- 对 hypothyroidism-PAD 和 hyperthyroidism-PAD 提出的病理生理路径的分析.
主要成果:
- 甲状腺功能障碍和甲状腺功能障碍都与心血管疾病和死亡率的增加有关.
- 甲状腺功能低下-PAD的潜在机制包括内皮功能障碍,血压变化,脂质不良和炎症.
- 甲状腺功能增高-PAD的潜在机制包括高动态循环,高静脉血压,高凝固性和动脉炎症.
结论:
- 甲状腺功能障碍对心血管并发症构成重大风险,包括外围动脉疾病.
- 了解具体机制对于在甲状腺患者中开发针对PAD的临床干预措施至关重要.
- 需要进一步的临床试验以PAD终点为重点,以充分调查这些关联.
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