非12α-氧化胆汁酸通过改善肠道植物,促进肠道发育和胆汁酸合成来改善小猪生长性能
Jianwei Qin1, Xinke Wei1, Mingming Cao1
1College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Animals : an open access journal from MDPI
|November 14, 2023
概括
非12α-基胆酸 (NBA) 补充改善了小猪生长性能和营养消化能力. NBA还积极调节胆汁酸代谢,肠道形态和肠道微生物群组成.
科学领域:
- 动物营养 动物营养
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 胆汁酸 (BAs) 是重要的乳化剂和生物活性物质,参与营养吸收和生理调节.
- 非12α-化胆酸 (NBA) 是一种特定的BA类,在动物生理学中具有潜在的作用.
研究的目的:
- 研究NBA补充剂对小猪生长表现,胆酸代谢和肠道菌群的影响.
- 确定NBA的最佳剂量,以改善小猪的健康和生产力.
主要方法:
- 一项涉及四组小猪的养试验,补充了不同剂量的NBA (0,60,120,180毫克/公斤).
- 评估生长参数,营养物质的消化能力 (原油,有机物质) 和肠道形态 (维卢斯高度).
- 通过16SrDNA测序分析血清生物化学标记物 (尿素,肌),与胆酸代谢相关的基因表达 (FXR,CYP27A1,NTCP) 和肠道微生物群组成的分析.
主要成果:
- NBA补充剂显著提高了最终体重,平均每日料摄入量,平均每日取量以及原油脂肪和有机物质的消化能力.
- 随着NBA补充剂的使用,人们观察到阴和阴中的高度增加,以及血清尿素和肌水平升高.
- NBAs通过降低肝脏FXR mRNA丰富度和增加CYP27A1和NTCP mRNA丰富度来调节胆酸输肝循环,同时也降低了叶FXR mRNA.
- 显著丰富Lactobacillus_Johnsonii和减少Streptococcus_alactolyticus被注意到,同时增加了结肠中的短链脂肪酸 (SCFA).
结论:
- 补充非12α-氧化胆酸有效改善小猪生长性能和营养利用.
- NBAs积极影响肠道发育,胆酸代谢途径,并促进更健康的肠道微生物环境.
- 这些发现表明,NBA是一种有前途的料添加剂,可以提高小猪的生产力和肠道健康.
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