随访COVID-19肺炎的定量CT:与肺功能测试的关系
Davide Colombi1, Marcello Petrini1, Camilla Risoli1
1Radiology Unit, Department of Radiological Functions, AUSL Piacenza, Via Taverna 49, 29121 Piacenza, Italy.
Diagnostics (Basel, Switzerland)
|November 14, 2023
概括
在COVID-19肺炎后进行定量胸部CT随访可以识别不可逆转的肺损伤. 在CT扫描中,低衰减区域与肺功能减弱相关,这表明潜在的长期呼吸问题.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 量化胸部计算机断层扫描 (CT) 在监测COVID-19肺炎恢复中的实用性仍在争论中.
- 评估COVID-19后的长期肺部健康状况对于患者管理至关重要.
研究的目的:
- 调查肺功能测试 (PFT) 与定量CT参数之间的关联.
- 在COVID-19肺炎发作后至少六个月评估CT发现.
主要方法:
- 包括40名患有COVID-19肺炎的成年患者,他们进行了基线和随访CT扫描 (发病后≥6个月).
- 肺功能测试 (PFTs) 在随访CT后的6个月内进行.
- 使用软件和视觉评估分析了包括低衰减区域 (%LAA) 在内的定量CT参数.
主要成果:
- 在%LAA (<950 HU) 和FEV1/FVC比率 (rho -0.410,p=0.008) 和%DLCO (rho -0.426,p=0.017) 之间发现了显著的反向相关性.
- 其他定量CT参数与PFT没有显著的关联 (p > 0.05).
结论:
- 在COVID-19肺炎后至少六个月的随访CT扫描显示了%LAAs.
- %LAAs与%DLCO相反相关,可能作为不可逆转的肺损伤标志物.
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