作为预后生物标志物,在没有心力衰竭的第一次急性心肌梗塞患者中使用加列-3
Rada M Vucic1,2, Olivera M Andrejic3, Dragana Stokanovic4
1Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica Street 69, 34000 Kragujevac, Serbia.
Diagnostics (Basel, Switzerland)
|November 14, 2023
概括
在急性心肌梗塞 (AMI) 发作后24小时内测量的加勒-3 (Gal-3) 血水平可以预测主要心血管不良事件 (MACE). 大动脉根Gal-3度是AMI患者六个月MACE的强有力的预后标志物.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 临床预后 临床预后
背景情况:
- 加勒-3 (Gal-3) 涉及急性心肌梗塞 (AMI) 后的心脏重塑.
- 预后标记对于改善AMI患者的生存率和生活质量至关重要.
研究的目的:
- 评估在急性心肌梗塞 (AMI) 患者中作为预后生物标志物的加勒-3 (Gal-3) 血度.
- 评估Gal-3在AMI后六个月内对主要心血管不良事件 (MACE) 的预测价值.
主要方法:
- 包括59名AMI患者和保存的喷射分数.
- 从多个部位 (大动脉根,大腿/半径动脉,冠状动脉鼻,肘部静脉) 开始的24小时内测量了Gal-3的血度.
- 在六个月的随访期评估主要不良心血管事件 (MACE).
主要成果:
- 20名患者 (34%) 在AMI后6个月经历了MACE.
- 大动脉根和大腿/半径动脉的Gal-3度独立预测了六个月的MACE.
- 大动脉根Gal-3度 (切断值≥10.86 ng/mL) 与大腿/半径动脉测量相比,对MACE或死亡 (AUC 0.858) 的预测值更高.
结论:
- 在胸痛发作后24小时内,在冠状动脉血管学测量时,特别是从大动脉根部测量出的加勒-3血度,是AMI患者的宝贵预后生物标志物.
- 这一发现有助于在AMI后六个月内识别患有较高心血管不良事件风险的患者.
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