一项关于父母年龄和儿童脏瘤的观察性病例控制研究
Georgios Politis1, Stefan Wagenpfeil2, Nils Welter1
1Department of Pediatric Oncology and Hematology, Saarland University, 66421 Homburg, Germany.
Cancers
|November 14, 2023
概括
这项研究发现,父母年龄与儿童癌 (威尔姆斯瘤) 发病率之间没有联系. 威尔姆斯瘤的存活率取决于癌症的类型和阶段,而不是父母的年龄或诊断年份.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症流行病学 癌症流行病学
- 遗传学和危险因素 遗传学和危险因素
背景情况:
- 威尔姆斯瘤 (WT) 是一种常见的儿童癌,结果通常良好,但其发展和复发的风险因素尚不清楚.
- 父母年龄是某些儿童疾病的已知因素,并且已被研究为儿童癌症的潜在风险因素.
研究的目的:
- 调查出生时母亲和父亲年龄之间的关联以及儿童中威尔姆斯瘤和非威尔姆斯瘤的发病率.
- 为了确定父母的晚年是否与患儿脏瘤的风险更高有关.
主要方法:
- 分析了1990-2019年间3,991名多中心研究 (SIOP9/GPO,SIOP 93-01/GPOH,SIOP 2001/GPOH) 的患者数据.
- 研究患者的父母年龄与德国活产婴儿的大型对照数据库 (超过1900万例) 的比较.
- 统计分析以评估父母年龄与瘤发病率之间的相关性,考虑瘤亚型,综合征,诊断年份和患者存活率.
主要成果:
- 发现母亲或父亲出生时的年龄较高与儿童瘤发病率增加无关.
- 尽管在研究期间 (1990-2019) 父母平均年龄增加,但儿童癌率并没有相应增加.
- 患者的生存率独立于父母的年龄和诊断年龄,但受到瘤组织学和阶段的显著影响.
结论:
- 先进的父母年龄不是威尔姆斯瘤或其他儿童脏瘤发生的重要风险因素.
- 威尔姆斯瘤的结果主要取决于既定的预后因素,如组织学和阶段,而不是父母的年龄.
- 这项研究提供了强有力的证据,反对父母年龄和儿童癌发病率之间的联系,有助于更清楚地理解WT病因.
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