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非编码RNA在肝细胞癌进展中的作用:从经典到新奇的临床病原遗传学影响

Mario Romeo¹, Marcello Dallio¹, Flavia Scognamiglio¹

¹Hepatogastroenterology Division, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.

|November 14, 2023

概括

非编码RNAs (ncRNAs) 是肝细胞癌 (HCC) 发展的关键调节者. 了解它们在HCC进展中的作用,特别是与非酒精性脂肪性肝病 (NAFLD) 相关的作用,提供了新的诊断和治疗策略.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

肝细胞癌 (HCC) 是一种主要的全球性癌症,发病率不断上升,特别与非酒精性脂肪性肝病 (NAFLD) 相关.
即使在NAFLD的非肝炎阶段,HCC也可能发生,这突显了对更好的理解和管理的迫切需要.
目前的研究重点是推动HCC的分子途径,以改善预后和治疗方法.

研究的目的:

审查失调的非编码RNAs (ncRNAs) 在HCC进展中的作用.
分析HCCC中ncRNAs影响的分子通路,考虑各种病因.
探索ncRNAs作为HCC的诊断,预后和治疗工具的临床适用性.

主要方法:

对HCCC中ncRNA研究的文献综述.
通过小ncRNAs (sncRNAs) 和长ncRNAs (lncRNAs) 调节的分子通路的分析.
研究ncRNA与免疫反应,氧化应激和肠道微生物群在HCC病变发生过程中的相互作用.

主要成果:

失调的sncRNAs和lncRNAs显著影响HCC进展机制.
在HCC临床实践中,ncRNAs显示出作为生物标志物和治疗点的潜力.
新兴证据将ncRNA与免疫调节,氧化应激和肝癌中的肠道微生物群联系起来.

结论:

ncRNAs是HCC发展和进展的关键参与者,特别是在NAFLD相关的病例中.
向ncRNAs为新型HCC诊断和治疗提供了一个有希望的途径.
ncRNAs,免疫,氧化应激和微生物群之间的相互作用为HCC病原体边界提供了新的见解.

关键词:

肝癌肝癌是一种肝癌.没有编码的RNAs.翻译医学是一种翻译医学.

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