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在栓塞之后,PD-L1和HIF-2α在头部和部偏结瘤的上调

Alessa Fischer¹, Umberto Maccio², Katharina Wang³

¹Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), University of Zurich (UZH), Rämistrasse 100, CH-8091 Zurich, Switzerland.

|November 14, 2023

概括

头部和部偏角质瘤的栓塞会导致缺氧,增加PD-L1和HIF-2α的表达. 这表明在晚期疾病中有针对性治疗的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

缺氧促进瘤进展和免疫抑制,上调PD-L1,免疫治疗的目标.
缺氧和PD-L1在染细胞瘤和偏结瘤 (PPGL) 中的作用,特别是在栓塞后,还没有得到充分研究.

研究的目的:

为了研究低氧诱导因子2-alpha (HIF-2α) 和PD-L1在PPGL的表达与没有先前栓塞.
评估HIF-2α和PD-L1作为PPGL患者治疗反应的潜在生物标志物.

主要方法:

免疫组织化学 (IHC) 用于分析来自25名患者的29个PPGL瘤样本.
瘤样本被分析为PD-L1和HIF-2α的表达.
患者根据他们是否接受了手术前栓塞进行了分层.

主要成果:

用栓塞治疗的头类瘤 (HNPGLs) 与没有栓塞治疗的患者相比,显著增加PD-L1表达 (中位数15%) (中位数0%,p=0.008).
经过先前栓塞的HNPGL也表现出明显更高的HIF-2α阳性 (中位数为40%) 比没有 (中位数为0%,p=0.016).

结论:

栓塞诱导缺氧,导致HNPGLs中的HIF-2α和PD-L1表达增加.
这些发现支持HIF-2α和检查点抑制剂在高级或转移性HNPGLs中用于向治疗的潜在用途.

关键词:

如果HIF2α 在HNPGL的基础上.在PD-L1中.抛售者可能会变得更强大.血栓塞栓是什么意思血栓塞栓是什么意思缺氧缺氧是指缺氧的情况.

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