定义瘤微环境作为有效的GEP-NENs免疫疗法的可能目标-系统性审查
Paulina Chmiel1, Paulina Rychcik-Pazyrska1, Rafał Stec1
1Department of Oncology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Cancers
|November 14, 2023
概括
本综述总结了胃肠胰腺神经内分泌瘤 (GEP-NETs) 中的瘤免疫微环境. 了解免疫细胞透和细胞因子等因素对于开发针对GEP-NETs的新免疫疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 神经内分泌瘤 (NENs) 是多种恶性瘤,胃肠胰腺神经内分泌瘤 (GEP-NETs) 是最常见的类型.
- 对GEP-NET的最佳治疗策略仍然具有挑战性,因为它们的起源和特征各不相同.
- 瘤微环境 (TME) 显著影响癌症的发展和对治疗的反应,需要对GEP-NET有更深入的理解.
研究的目的:
- 在GEP-NET中描述瘤免疫微环境 (TME).
- 探索基于TME组成的GEP-NET的潜在免疫治疗策略.
- 综合目前关于免疫细胞透,免疫检查点,细胞因子,新血管生成和GEP-NET TME内的微生物组的研究.
主要方法:
- 科学文献的系统审查.
- 在PubMed,Web of Science和Scopus数据库中进行的搜索.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 从对3800个出版物的初步搜索中,包括了28篇相关文章.
- 该综述综合了GEP-NET TME中免疫细胞种群,免疫检查点表达,细胞因子概况,新血管生成和微生物组合的数据.
- 确定了影响GEP-NET TME的关键因素及其与免疫系统的相关性.
结论:
- 描述GEP-NET TME对于推进有针对性的免疫疗法至关重要.
- 对GEP-NETs免疫环境的进一步研究可以指导开发更有效的治疗方案.
- 了解TME中的瘤细胞和免疫系统之间的相互作用对于改善患者的治疗结果至关重要.
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