相关实验视频

Updated: Jul 11, 2025

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

在口腔状细胞癌中血液学参数的预后值

Lorenzo Fernandes Moça Trevisani¹, Isabelle Fernandes Kulcsar², Marco Aurélio Vamondes Kulcsar³

¹Programa de Pós-Graduação em Anestesiologia, Ciências Cirúrgicas e Medicina Perioperatória, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, Brazil.

|November 14, 2023

概括

红细胞分布宽度 (RDW) 大于14.3%是口腔状细胞癌 (OSCC) 患者生存的可靠指标. 其他血液学指数也显示出预后价值,需要进一步的临床研究.

科学领域:

在瘤学瘤学.
血液学血液学血液学
临床病理学临床病理学

背景情况:

口腔状细胞癌 (OSCC) 是一个重大的公共卫生挑战.
目前的预后因素主要集中在瘤特征上,缺乏患者特定的指标.
在OSCC管理中需要可靠的患者相关预后指数.

研究的目的:

在被诊断为OSCC的患者中调查各种血液学指数的预后意义.
确定与OSCC中预后较差相关的患者特异性标记.

主要方法:

在600名接受治疗意图治疗的OSCC患者 (手术+/-辅助疗法) 的回顾性队列研究.
在手术前进行的实验室测试 (包括RDW,NLR,PLR,SII).
从医疗记录中收集的人口和临床数据.

主要成果:

多变量分析确定了血管淋巴细胞侵袭,pT4a/b瘤,外节外流和RDW> 14.3%作为减少整体存活的独立风险因素.
单变量分析显示,与周围神经侵袭,血管淋巴侵袭,pT4瘤,淋巴结转移,额外输液,RDW> 14.3%,NLR> 3.38,PLR> 167.3和SII> 416.1.1.3相关的死亡率增加.
在随访期间,该队列的总死亡率为48.8%.

结论:

红细胞分布宽度 (RDW) 超过14.3%是OSCC患者整体存活时间的验证预后标记.
建议进行进一步的研究,以探索其他血液学指数作为OSCC的预后工具的临床实用性.

关键词:

在RDW和RDW方面.口腔状细胞癌的癌症.预后预后预后

更多相关视频

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

相关概念视频

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...