晚期肝细胞癌的存活率改善,依时代顺序治疗
Yoshiko Nakamura1, Masashi Hirooka1, Atsushi Hiraoka2
1Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Cancers
|November 14, 2023
概括
连续的全身疗法显著改善了晚期肝细胞癌 (HCC) 患者的整体存活率. 在进展后继续治疗有利于在HCC管理中获得更好的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 系统疗法现在是晚期肝细胞癌 (HCC) 的首要治疗方法.
- 顺序治疗策略对HCC预后的影响尚不清楚.
研究的目的:
- 评估顺序系统治疗对晚期HCC患者预后的影响.
- 分析随着时间的推移,HCC病因和治疗的趋势.
主要方法:
- 对336名在2009年至2022年期间接受治疗的高级HCC患者进行了回顾性研究.
- 根据系统性治疗开始的时间 (2009-2013,2014-2018,2019-2022) 将患者分组为组.
- 使用Cox比例危险模型对治疗线,治疗疗效,整体存活率 (OS) 和预后因素进行比较.
主要成果:
- 观察到HCC病因从病毒性肝炎转变为非病毒性肝炎.
- 接受两种以上疗法的患者比例随着时间的推移显著增加 (1.2%至17.0%).
- 在各个时期 (14.3至31.0个月) 中,中位 OS 显著改善.
结论:
- 序列疗法已经大大改善了高级HCC的结果.
- 诸如不完整的第一线反应,高瘤负担,肝外转移和升高的AFP等因素与更短的生存周期有关.
- 建议在进展后继续连续治疗,以提高HCC的存活率.
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