动脉样硬化及其相关实验室生物标志物
Vittoriano Della Corte1, Federica Todaro1, Marco Cataldi1
1Internal Medicine and Stroke Care Ward, Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialities (ProMISE) "G. D'Alessandro", University of Palermo, Piazza delle Cliniche n.2, 90127 Palermo, Italy.
International journal of molecular sciences
|November 14, 2023
概括
本综述检查了用于动脉样硬化,慢性炎症性疾病的新型血清生物标志物. 识别这些标志物可以改善心血管风险预测和冠状动脉疾病等疾病的临床决策.
科学领域:
- 心血管医学 心血管医学
- 生物标志物发现发现
- 炎症性疾病 炎症性疾病
背景情况:
- 动脉样硬化是一种慢性炎症状况,是冠状动脉疾病 (CAD) 和外周动脉疾病 (PAD) 等主要心血管疾病 (CVD) 的基础.
- 动脉中的斑块积累缩小了血管,阻碍了血液流动,导致组织缺氧,这可能导致中风和心肌梗塞,是全球主要的死亡原因.
- 目前的心血管风险预测模型依赖于传统的风险因素,但可能会从纳入新生物标志物中获益.
研究的目的:
- 对与动脉样硬化相关的血清生物标志物的最新文献进行全面审查.
- 评估这些生物标志物的潜力,以提高心血管风险预测模型的准确性.
- 探索将新生物标志物纳入指导患者管理决策中的临床实用性.
主要方法:
- 系统的文献搜索关于动脉样硬化血清生物标志物的最新出版物.
- 对调查单个和组合生物标志物的预测价值的研究进行分析.
- 对生物标志物融入现有心血管风险评估框架的评估.
主要成果:
- 已经确定了许多与动脉样硬化事件风险增加相关的血清生物标志物.
- 包括某些生物标志物,单独或在面板中,显示有可能提高心血管风险模型的预测准确性.
- 需要进一步的研究,以充分阐明这些新型标记物的临床实用性和最佳应用.
结论:
- 血清生物标志物是推动动脉样硬化风险评估的一个有希望的领域.
- 将验证的生物标志物纳入临床实践可以完善心血管风险分层,并个性化患者护理.
- 对生物标志物验证和临床实施的持续研究对于改善动脉样硬化疾病患者或风险患者的治疗结果至关重要.
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