在装有氧气的纳米泡中的封装增强了光激活黄素的抗菌有效性
Zunaira Munir1, Chiara Molinar2, Giuliana Banche3
1Department of Neurosciences, University of Turin, 10125 Torino, Italy.
International journal of molecular sciences
|November 14, 2023
概括
黄素纳米泡,特别是含有氧气的纳米泡,对抗性菌株表现出强大的抗菌活性. 这种环保方法为医疗保健和农业中传统抗生素提供了有希望的替代方案.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 抗菌研究 抗菌研究
背景情况:
- 抗生素耐药性是医疗保健和农业的关键全球挑战.
- 对于"绿色"和生物相容的抗菌剂的需求日益增长.
- 黄素是一种天然化合物,在治疗用途中,其溶解性和稳定性受到限制.
研究的目的:
- 使用纳米泡泡技术来增强黄素的抗菌疗效和稳定性.
- 为了研究氧气加载和光激活对基于黄素的纳米泡的协同效应.
- 开发环保的替代方法来打击抗生素耐药性.
主要方法:
- 合成了含有黄素的酸盐外纳米泡 (Curc-CS-NBs) 和含有氧气的变体 (Curc-Oxy-CS-NBs).
- 纳米泡的特点是它们的释放特性和稳定性.
- 使用最小抑制度 (MIC) 试验,对各种细菌菌株 (例如,黄金葡萄球菌,菌,大肠杆菌) 进行抗菌疗效评估.
- 使用LED照射的光激活来评估增强的抗菌活性.
主要成果:
- 在纳米泡中封装黄素显著提高了其稳定性和可溶性.
- 光激活的Curc-Oxy-CS-NBs表现出优异的抗菌活性,大大降低了S. aureus*的MIC值,达到12μg/mL.
- 无论是Curc-CS-NBs还是Curc-Oxy-CS-NBs,都显示了对*E. faecalis*的减少MIC.
- 装有氧气的纳米泡与LED辐射相结合,在杀死细菌方面非常有效,通过ROS生产诱导膜泄漏,特别是对大肠杆菌.
结论:
- 含有黄素的纳米气泡,特别是含有氧气的纳米气泡,具有强大且增强的抗菌特性.
- 这项技术为克服抗生素耐药性的可行策略提供了可行策略.
- 开发的纳米泡为农业和医疗保健应用提供了一个有希望的环保替代方案.
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