在Lingo-1中的遗传和表观遗传调节:对精神分裂症病例对照研究中的认知功能和白质微观结构的影响
Jessica L Andrews1, Andrew Zalesky2, Shalima Nair3
1School of Medical, Indigenous and Health Sciences, and Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.
International journal of molecular sciences
|November 14, 2023
概括
这项研究表明,与Lingo-1相关的遗传和表观遗传因素与精神分裂症有关,影响患者的认知功能和白质完整性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 富含白蛋白的重复和免疫球蛋白域含有蛋白1 (Lingo-1) 对参与学习和记忆的神经元过程至关重要.
- 精神分裂症的特征是学习和记忆受损,但Lingo-1在这种疾病中的作用以前没有被研究过.
研究的目的:
- 研究Lingo-1与精神分裂症的遗传和表观遗传关联.
- 检查Lingo-1遗传变异,甲基化,认知功能障碍和精神分裂症中的白质完整性之间的关系.
主要方法:
- 一个病例控制研究,每个组 (精神分裂症和对照组) 共有268名参与者.
- 在Lingo-1 3'-UTR区域中分析单核酸多态 (SNP,rs3144) 和CpG位点甲基化.
- 结构磁共振成像 (MRI) 用于评估参与者的子集中的白质完整性.
主要成果:
- 在精神分裂症组 (p=0.03) 中,rs3144小等位基因更频繁,并且与认知缺陷和白质完整性有关.
- 与精神分裂症患者 (p=0.032) 相比,对照组中 rs3144 附近的 CpG 部位具有高甲基化 (p=0.032).
- rs3144基因型预测属于精神分裂症小组的成员,具有普遍认知缺陷.
结论:
- 这是第一个表明Lingo-1在精神分裂症中的潜在遗传和表观遗传风险因素的研究.
- 在精神分裂症病理生理学中,Lingo-1的遗传和表观遗传变化可能与认知功能障碍和白质完整性变化有关.
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