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TOR复合体1:调节营养信号和细胞周期进展

Magdalena Foltman^1,2, Alberto Sanchez-Diaz^1,2

¹Mechanisms and Regulation of Cell Division Research Unit, Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, 39011 Santander, Spain.

International journal of molecular sciences

|November 14, 2023

概括

拉帕素复合体1 (TORC1) 途径的标协调了酵母细胞的细胞生长与细胞循环. 本综述详细介绍了TORC1活动如何影响细胞循环的进展,维持恒常和染色体稳定.

科学领域:

细胞生物学细胞生物学
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

拉巴胺素 (TOR) 信号通路的目标是真核生物中细胞过程的高度保守的调节器.
托尔复合体1 (TORC1) 集成环境信号来控制细胞生长和增殖.
细胞生长和细胞循环之间的协调对于维持细胞大小平衡和基因组稳定性至关重要.

研究的目的:

审查TORC1调节发芽酵母 (Saccharomyces cerevisiae) 细胞循环的分子机制.
突出TORC1活动动态在细胞周期进展中的重要性.
为了强调酵母作为理解哺乳动物的模型的作用,mTORC1.1.

主要方法:

关于Saccharomyces cerevisiae中TORC1信号传递和细胞周期调节的既定研究的文献综述.
分析连接TORC1活动到细胞周期检查点和进展的分子通路.
与哺乳动物目标对拉巴胺素复合物1 (mTORC1) 功能的比较分析.

主要成果:

TORC1活动是动态调节的,连续的高和低活动周期有助于细胞周期的正常进展.
TORC1影响细胞周期的关键事件,包括DNA复制,线粒分裂和细胞运动.
干扰TORC1信号传递可能导致细胞生长失衡和细胞周期缺陷.

结论:

在酵母中,TORC1在将细胞生长控制与细胞周期进展联系起至关重要的作用.
了解酵母细胞中介的TORC1细胞循环调节,可以了解包括人类在内的其他真核生物的保存机制.
动态调节TORC1活动对于维持细胞平衡和防止基因组不稳定至关重要.

关键词:

它们中的一种是S. cerevisiae.这就是TOROR.在TORC1中,开花的酵母酵母是什么意思细胞循环中的细胞循环.细胞生长细胞的生长.

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