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相关概念视频

The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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Positive Regulator Molecules02:39

Positive Regulator Molecules

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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相关实验视频

Updated: Jul 11, 2025

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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TOR复合体1:调节营养信号和细胞周期进展.

Magdalena Foltman1,2, Alberto Sanchez-Diaz1,2

  • 1Mechanisms and Regulation of Cell Division Research Unit, Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, 39011 Santander, Spain.

International journal of molecular sciences
|November 14, 2023
PubMed
概括

拉帕素复合体1 (TORC1) 途径的标协调了酵母细胞的细胞生长与细胞循环. 本综述详细介绍了TORC1活动如何影响细胞循环的进展,维持恒常和染色体稳定.

关键词:
它们中的一种是S. cerevisiae.这就是TOROR.在TORC1中,开花的酵母酵母是什么意思细胞循环中的细胞循环.细胞生长细胞的生长.

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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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相关实验视频

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

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科学领域:

  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 拉巴胺素 (TOR) 信号通路的目标是真核生物中细胞过程的高度保守的调节器.
  • 托尔复合体1 (TORC1) 集成环境信号来控制细胞生长和增殖.
  • 细胞生长和细胞循环之间的协调对于维持细胞大小平衡和基因组稳定性至关重要.

研究的目的:

  • 审查TORC1调节发芽酵母 (Saccharomyces cerevisiae) 细胞循环的分子机制.
  • 突出TORC1活动动态在细胞周期进展中的重要性.
  • 为了强调酵母作为理解哺乳动物的模型的作用,mTORC1.1.

主要方法:

  • 关于Saccharomyces cerevisiae中TORC1信号传递和细胞周期调节的既定研究的文献综述.
  • 分析连接TORC1活动到细胞周期检查点和进展的分子通路.
  • 与哺乳动物目标对拉巴胺素复合物1 (mTORC1) 功能的比较分析.

主要成果:

  • TORC1活动是动态调节的,连续的高和低活动周期有助于细胞周期的正常进展.
  • TORC1影响细胞周期的关键事件,包括DNA复制,线粒分裂和细胞运动.
  • 干扰TORC1信号传递可能导致细胞生长失衡和细胞周期缺陷.

结论:

  • 在酵母中,TORC1在将细胞生长控制与细胞周期进展联系起至关重要的作用.
  • 了解酵母细胞中介的TORC1细胞循环调节,可以了解包括人类在内的其他真核生物的保存机制.
  • 动态调节TORC1活动对于维持细胞平衡和防止基因组不稳定至关重要.