自闭症谱系障碍中的TLDc域含基因:氧化应激反应中的新参与者
Cinzia Zucchini1, Carmela Serpe1, Paola De Sanctis1
1Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
International journal of molecular sciences
|November 14, 2023
概括
氧化应激与自闭症谱系障碍 (ASD) 有关. 这项研究在ASD儿童中发现TLDc域mRNA和TUG1RNA的增加,这表明一种新途径调节了ASD中氧化应激反应.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种与氧化压力相关的神经发育状况.
- 对于参与氧化应激反应和神经保护的蛋白质来说,TLDc域至关重要.
- 具有TLDc域的关键人类蛋白质包括OXR1,TLDC1,NCOA7,TBC1D24和C20ORF118.8.
研究的目的:
- 研究TLDc域含有mRNAs,microRNAs (200b-3p, 32-5p) 和长非编码RNA TUG1在调节ASD中的氧化应激反应中的作用.
- 探索TLDcmRNA表达,ASD严重程度和炎症之间的潜在相关性.
主要方法:
- 在外周血液单核细胞 (PBMC) 中对TLDcmRNAs (OXR1,TLDC1) 和TUG1进行定量分析.
- 与ASD儿童和神经类型发育 (NTD) 儿童之间的基因表达水平的比较.
- 基因表达,儿童自闭症评分表 (CARS) 分数和炎症标志物之间的相关性分析.
主要成果:
- 与NTD对照组相比,在ASD儿童中观察到显著升高的OXR1和TLDC1mRNA水平.
- 在ASD患者中发现了增加的TUG1mRNA表达,这表明TLDc蛋白功能的潜在调节作用.
- 在某些TLDcmRNA,CARS得分和炎症基因表达之间确定了积极的相关性.
结论:
- 这些发现表明,在ASD的病理生理学中,涉及TLDc域蛋白,TUG1和氧化应激的新生物学途径.
- 这一途径需要进一步调查ASD的潜在诊断或治疗点.
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