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在危急COVID-19患者中增加了galactin-3水平

Ioanna Nikitopoulou¹, Alice G Vassiliou¹, Nikolaos Athanasiou¹

¹1st Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece.

International journal of molecular sciences

|November 14, 2023

概括

在严重的COVID-19患者中,加勒-3水平升高与危急疾病和重症监护室 (ICU) 死亡率相关. 这种蛋白质可以作为预测COVID-19患者结果的关键生物标志物.

科学领域:

生物化学生化学
免疫学免疫学免疫学
关键护理医学关键护理医学

背景情况:

严重的COVID-19的特点是高炎症和器官损伤,通常需要进入重症监护室 (ICU).
参与炎症和纤维化的一种蛋白质加勒-3在传染病病理学中具有潜在的作用.
了解COVID-19严重程度和预后的生物标志物对于临床管理至关重要.

研究的目的:

为了研究甲基-3血清水平与COVID-19的临床严重程度之间的关联.
为了评估galectin-3的预后准确性来预测COVID-19患者的ICU死亡率.
为了验证两组独立的患者队伍的发现.

主要方法:

在235名COVID-19患者的血清中测量了胆固醇-3水平.
关键和不那么严重的COVID-19病例之间的加勒-3水平的比较.
使用接收器操作特征 (ROC) 曲线和多变量分析,分析与ICU存活率相关的加勒-3水平.
在第二个COVID-19患者队列中验证结果.

主要成果:

在危急的COVID-19患者中,与较轻的病例 (2.9 ng/mL) 相比,中位胆-3水平显著更高 (7.2 ng/mL).
在ICU中的未幸存者比幸存者 (5.8 ng/mL) 有明显更高的加勒-3水平 (9.1 ng/mL).
入院时的加勒-3度被确定为ICU死亡率的独立风险因素.

结论:

在严重的COVID-19中,加勒-3水平显著升高,与ICU死亡率相关.
盖莱克-3在预测COVID-19患者的ICU死亡率方面表现出预后准确性.
盖莱克-3成为评估住院COVID-19患者预后的潜在生物标志物.

关键词:

在 COVID-19 疫情中,病情严重,病情危急.盖莱克-3的使用方法死亡率死亡率

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