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Updated: Jul 11, 2025

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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染色质的动态组织的多尺度成像

Fabiola García Fernández1, Sébastien Huet2,3, Judith Miné-Hattab1

  • 1Laboratory of Computational and Quantitative Biology, CNRS, Institut de Biologie Paris-Seine, Sorbonne Université, 75005 Paris, France.

International journal of molecular sciences
|November 14, 2023
PubMed
概括

高分辨率成像显示染色质是一种动态的核结构,对基因组调节至关重要. 这项技术可视化染色体的组织和行为,特别是在DNA损伤反应期间.

关键词:
修复DNA的修复DNA的修复染色体的组织和动态.高分辨率成像成像技术

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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
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