微环境中的奇丁酶3-like-1表达与膀癌中中性粒细胞透有关
Ling-Yi Xiao1, Yu-Li Su2,3, Shih-Yu Huang2
1Department of Laboratory Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung 404327, Taiwan.
International journal of molecular sciences
|November 14, 2023
概括
胆酶3样-1 (CHI3L1) 在晚期膀癌中升高,与突起性中性粒细胞相关. 这一发现表明CHI3L1可能有助于评估接受化疗的患者中性粒细胞透.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 膀癌的复发和进展仍然是一个重大挑战,肌肉侵入性疾病的生存率很低.
- 胆酶3样-1 (CHI3L1) 涉及各种癌症,包括膀癌,并影响免疫细胞功能.
- 中性粒细胞透与改善膀癌生存结果有关,但其与CHI3L1的关系尚不清楚.
研究的目的:
- 在膀癌中调查基因酶3样-1 (CHI3L1) 水平与突瘤中性粒细胞透之间的关联.
- 确定CHI3L1表达是否与疾病侵袭性和化疗耐药性相关.
主要方法:
- 对GSE128959数据集的分析.
- 从接受化疗的膀癌队列中检查数据.
主要成果:
- 在具有侵入性疾病或化疗耐药性的膀癌患者中观察到更高的CHI3L1表达.
- 在CHI3L1表达和前瘤中性粒细胞透之间发现了正相关性.
- 增加的CHI3L1与参与中性粒细胞招募和透的基因有关.
结论:
- 胆酶3样-1 (CHI3L1) 表达与晚期膀癌中的前细胞中性粒细胞透有关.
- 在接受化疗的膀癌患者中,CHI3L1可作为评估中性粒细胞透的新型生物标志物.
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