相关实验视频

Updated: Aug 2, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

在缺血性中风中对大脑保护的临床翻译研究正在发展

Yinghui Li¹, Laurel E Schappell^1,2, Claire Polizu¹

¹Department of Neurology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794-8651, USA.

Journal of clinical medicine

|November 14, 2023

概括

尽管有先进的治疗方法,但许多缺血性中风患者面临残疾. 本综述探讨神经保护和大脑保护的策略,以改善中风的结果,并促进大脑的修复.

科学领域:

神经学神经学
翻译科学翻译科学
神经保护研究神经保护研究

背景情况:

缺血性中风会导致严重的残疾,即使使用血栓溶解和血栓切除等再输血疗法.
缺血半阴影的概念强调了中风后可以挽救的大脑区域.
神经保护的目的是尽量减少心脏病发作的扩张,减少二次损伤,促进修复,但临床翻译仍然具有挑战性.

研究的目的:

审查过去,现在和新兴的大脑保护策略的翻译科学.
通过考虑整个大脑,提出一个新的模式来优化中风的结果.

主要方法:

关于神经保护和大脑保护的临床前和临床研究的文献综述.
分析中风研究中的翻译差距.
综合现有知识,提出新的方法.

主要成果:

尽管进行了广泛的研究,但没有任何神经保护剂能够显著改善超越再注射疗法的结果.
大脑保护的概念将重点扩大到整个大脑对中风的反应.

结论:

在开发用于缺血性中风的有效神经保护剂方面,仍然存在显著的翻译差距.
需要一种新的大脑保护范式,通过考虑整个大脑来优化中风的结果.
对神经保护和大脑保护策略的持续研究对于推进中风治疗至关重要.

关键词:

大脑保护保护大脑激发性毒性激发性毒性这是一种炎症炎症炎症炎症.缺血-再输血损伤的损伤缺血性中风中风氧化应激是一种氧化应激.干细胞是干细胞的组成部分.翻译研究是翻译研究.

更多相关视频

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

相关概念视频

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...