初级甲状腺功能障碍和心血管疾病:使用临床自然语言处理系统和大数据分析的协会研究
Pedro Iglesias1,2, Javier Arias3, Guillermo López3
1Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de AranaMajadahonda, 28222 Madrid, Spain.
Journal of clinical medicine
|November 14, 2023
概括
原发性偏甲状腺症 (PHPT) 与心血管风险因素和疾病的增加有关. 这项研究证实了PHPT与大量患者群体中主要心血管问题的显著关联.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 原发性偏甲状腺症 (PHPT) 是一种与心血管疾病 (CVD) 有潜在联系的疾病.
- 了解这些关联对于患者管理和风险分层至关重要.
- 以前的研究表明存在联系,但需要进行大规模的数据分析.
研究的目的:
- 评估原发性副甲状腺功能障碍症 (PHPT) 和主要心血管风险因素 (CVRFs) 之间的关联.
- 评估PHPT与各种心血管疾病 (CVD) 之间的关系.
- 在本次评估中利用人工智能 (AI) 工具进行数据分析.
主要方法:
- 一项使用电子健康记录 (EHR) 的观察性,回顾性研究.
- 包括699,157名成年患者,重点关注6515名被诊断患有PHPT.
- 多变量回归分析以确定独立的关联.
主要成果:
- 患有PHPT的患者显示高血压,血脂不良,糖尿病和吸烟的频率显着更高.
- 在PHPT队列中,中风,缺血性心脏病,心房动,深静脉血栓形成和肺栓塞的发生率明显高于PHPT队列.
- PHPT与所有评估的心血管疾病独立相关 (p < 0.001).
结论:
- 初级甲状腺功能障碍症与主要心血管风险因素有显著的关联.
- 在PHPT和一系列心血管疾病之间存在强烈的,独立的联系.
- 这些发现凸显了PHPT患者心血管监测的重要性.
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