在心血管系统的RAAS好伙计
Ilaria Caputo1, Giovanni Bertoldi1, Giulia Driussi1
1Nephrology, Dialysis and Transplantation Unit, Department of Medicine-DIMED, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.
Journal of clinical medicine
|November 14, 2023
概括
保护性氨酸- ангиотензин- алдостерон系统 (RAAS) 轴,涉及ACE2/Ang 1-7/MasR,抵消有害的RAAS影响. 加强这一轴为心血管疾病提供了治疗策略.
科学领域:
- 心血管科学 心血管科学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 氨酸- ангиотензин- алдостерон系统 (RAAS) 有一个经典的促炎臂 (ACE/Ang II/AT1R) 和一个反调节的保护臂.
- 保护臂涉及ACE2,抗素-(1-7) [Ang 1-7]/Mas受体 (MasR),以及抗素-1/9 [Ang 1-9].
- 这个轴在预防炎症,氧化应激,高血压和心血管改造方面发挥着至关重要的作用.
研究的目的:
- 审查ACE2/Ang 1-7/MasR和Ang 1-9轴的有益影响.
- 突出其在缓解心血管并发症中的作用.
- 强调其在管理氧化应激,血管功能障碍和器官损伤方面的治疗潜力.
主要方法:
- 对RAAS反监管轴研究的文献综述.
- 对研究ACE2,Ang 1-7/MasR和Ang 1-9的研究分析.
- 综合证据关于它们对心血管健康的影响.
主要成果:
- ACE2/Ang 1-7/MasR和Ang 1-9轴有效地抵消了经典RAAS的不利影响.
- 这个轴的激活显示出对炎症和氧化应激的保护功能.
- 证据支持其在预防高血压和心血管改造方面的作用.
结论:
- 增强ACE2/Ang 1-7/MasR和Ang 1-9轴是对心血管疾病的一种有前途的治疗策略.
- 针对这种保护臂提供了一种新的方法来管理心血管并发症.
- 对这一轴的进一步研究可能会导致血管功能障碍和器官损伤的新疗法.
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