光学引导的高频超声波以区分高风险的基底细胞癌亚型:单中心前性研究
Szabolcs Bozsányi1,2, Mehdi Boostani1, Klára Farkas1
1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary.
Journal of clinical medicine
|November 14, 2023
概括
光学引导的高频超声波 (OG-HFUS) 可以区分积极的基础细胞癌 (BCC) 亚型和低风险的亚型. 这种非侵入性成像支持皮肤癌的及时治疗决策.
科学领域:
- 皮肤病学 皮肤病学
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 基底细胞癌 (BCC) 是高加索人最常见的皮肤癌.
- 组织学亚型 (HST) 确定对于治疗至关重要,目前需要侵入性活检.
- 这项研究研究了光学引导的高频超声波 (OG-HFUS) 以区分攻击性的BCC HST.
研究的目的:
- 评估OG-HFUS在区分攻击性BCC HST和低风险BCC中的有效性.
- 开发和验证一个新的OG-HFUSBCC风险分类算法.
- 将OG-HFUS的诊断性能与传统的宏观和皮肤镜评估进行比较.
主要方法:
- 一项前性研究,涉及78个BCC的临床,皮肤镜和33MHzOG-HFUS检查.
- 开发使用63个BCC的OG-HFUS风险分类算法,并对15个BCC进行验证.
- 组织学分析证实了BCC亚型;统计分析包括费舍尔的精确测试和ROC曲线分析.
主要成果:
- OG-HFUS通过不规则的形状,不清楚的边缘和不均的内部回声 (p < 0.0001) 确定了积极的BCC HST.
- 通过OG-HFUS算法获得的灵敏度 (82.4%) 和特异性 (91.3%) 比宏观/皮肤镜评估 (40.1%/73.1%) 高.
- 经验证的OG-HFUS算法显示了高的正预测值 (94.7%) 和负预测值 (78.6%).
结论:
- 通过使用不同的形态参数,OG-HFUS有效地识别了激进的基底细胞癌组织学亚型.
- 这种非侵入性成像技术有助于BCC早期治疗决策.
- OG-HFUS为BCC亚型分类提供了侵入性活检的有希望的替代方案.
关键词:
攻击性亚型 攻击性亚型基底细胞癌的癌症.活组织活检皮肤显微镜 (dermoscopy) 是一种可以检查皮肤的方法.早期检测 早期检测高频超声波是一种高频超声波.组织学亚型 组织学亚型其他非黑色素瘤性皮肤癌.这是一种外科切除术.更多相关视频
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