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儿童1型糖尿病:在先进的混合闭环胰岛素治疗中,年龄是否是决定因素?
Alfonso Lendínez-Jurado1,2, Juan Pedro López-Siguero1,2,3, Ana Gómez-Perea1,3
1Department of Pediatric Endocrinology, Hospital Regional Universitario de Málaga, 29011 Málaga, Spain.
Journal of clinical medicine
|November 14, 2023
概括
自动化胰岛素输送系统可以改善1型糖尿病 (T1D) 儿童的血糖控制. 在4岁后被诊断患有T1D的儿童在使用这些先进系统时表现出更好的结果.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生物医学工程 生物医学工程
- 糖尿病 技术 技术
背景情况:
- 持续的葡萄糖监测 (CGM) 和胰岛素集成可以增强成人血糖控制.
- 对这些综合系统的儿科研究,特别是它们与发病年龄的相关性,是有限的.
研究的目的:
- 评估自动胰岛素输送 (AID) 系统在患有1型糖尿病 (T1D) 的儿科患者中的有效性.
- 评估T1D发病时的年龄对AID系统的血糖控制结果的影响.
主要方法:
- 对28名患有T1D的儿科患者 (平均年龄12岁) 的前性研究.
- 患者按T1D发病时的年龄分组 (≤4年 vs>4年).
- 在实施MiniMedTM 780G AID系统后,血糖变量被监测了3个月.
主要成果:
- 在1个月和3个月后,观察到范围内的时间 (TIR) 和范围以上时间 (TAR) 的显著改善和减少.
- 在4岁后被诊断为T1D的患者与年轻发病组相比,表现出更好的血糖控制.
- 具体指标如TIR显著改善 (p < 0.009),而TAR1和TAR2则下降 (分别p < 0.009和p < 0.027).
结论:
- MiniMedTM 780G系统有助于在儿科T1D中实现共识的血糖目标,特别是那些晚发 (>4岁) 的儿童.
- 尽管实施了AID系统,但在儿童T1D中管理高血糖和血糖变异仍然具有挑战性.
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