相关实验视频

Updated: Jul 11, 2025

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization

Published on: October 24, 2011

发酵谷物通过使用天然酶来抑制酶活性和脂质生成

Jin-Sung Jun¹, Ye-Lim You², Ha-Jun Byun²

¹Naraentech Co., Ltd., Sanhangni-gil, Janggun-myeon, Sejong-si 30054, Republic of Korea.

Molecules (Basel, Switzerland)

|November 14, 2023

概括

与非发酵选项相比,发酵谷物酶表现出优越的抗氧化,抗炎和抗原作用. 这表明谷物酶是对代谢健康的有希望的食补充剂.

科学领域:

生物化学生物化学
营养科学营养科学
分子生物学分子生物学

背景情况:

富含酶的食物越来越多地被认为具有健康益处.
了解发酵和非发酵酶来源的比较效果对于饮食应用至关重要.
氧化应激,炎症和脂肪生成是代谢障碍的关键因素.

研究的目的:

为了比较发酵的谷物酶的抗氧化,抗炎和抗原性质与两个非发酵的富含酶的食物.
评估这些酶源在调节关键炎症和脂肪生成标志物的有效性.
为了确定最强效的酶来源,以作为食补充剂的潜在用途.

主要方法:

使用激素清除试验评估抗氧化活性.
量化总的多和黄含量.
测量了氧化物 (NO) 在脂聚糖 (LPS) 刺激的巨细胞中的产量.
分析了诸如诱导性氧化合成酶 (iNOS),循环氧化原酶-2 (COX-2) 和互白蛋白 (IL-1β,IL-6) 等炎症标志物的表达.
研究了对基因表达的影响,包括过氧酶增殖器激活受体 (PPAR)γ,CCAAT/增强剂结合蛋白 (C/EBP) α和脂肪酸结合蛋白 (FABP) 4.

主要成果:

发酵谷物酶表现出最高的激素清除活性和抗氧化成分含量.
所有测试的酶都抑制了氧化的产生,谷物酶和酶食物1显示出显著的影响.
谷物酶最有效地抑制了iNOS,COX-2和IL-1β的表达,而酶食物2影响了IL-6mRNA水平.
谷物酶显著抑制了关键脂肪原因子 (PPARγ,C/EBPα,FABP4) 的mRNA表达.
发酵谷物酶表现出比非发酵酶食品更强的抗炎和抗原作用.

结论:

与非发酵的富含酶的食物相比,发酵的谷物酶具有优越的抗氧化,抗炎和抗原性质.
谷物酶显示出作为一种饮食补充剂,用于控制炎症和脂肪生成的显著潜力.
这些发现支持在旨在预防或管理代谢障碍的策略中使用发酵谷物酶.

关键词:

脂质生成 (adipogenesis) 是一种抗氧化剂是一种抗氧化剂.富含酶的食物富含酶的食物谷物酶是一种谷物酶.炎症反应是一种炎症反应.代谢障碍代谢障碍是一种代谢障碍.

更多相关视频

Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol

Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol

Published on: October 24, 2016

Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production

Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production

Published on: September 20, 2016

相关概念视频

Microbial Fermentation

Microbial Fermentation

Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...

Fates of Pyruvate

Fates of Pyruvate

Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...

Lipid Digestion

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.

Enzymes

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...