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Agata Jabłońska-Trypuć¹, Urszula Wydro¹, Elżbieta Wołejko¹

¹Department of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bialystok University of Technology, Wiejska 45E Street, 15-351 Białystok, Poland.

Molecules (Basel, Switzerland)

|November 14, 2023

概括

常见的杀菌剂如博斯卡利德,cyprodinil和iprodione表现出雌激素活性,增加癌细胞活力和增殖. 这些内分泌干扰化合物诱导氧化应激,强调需要避免通过饮食接触农药.

科学领域:

环境毒理学环境毒理学
内分泌学在内分泌学.
癌症生物学癌症生物学

背景情况:

农药暴露,特别是来自饮食中的杀菌剂,正在增加.
杀菌剂是疑似内分泌干扰化合物 (EDC),其机制尚不清楚.
素食饮食增加了水果,蔬菜和谷物的农药暴露.

研究的目的:

为了研究博斯卡利德,cyprodinil和iprodione的内分泌干扰潜力.
评估这些杀菌剂对对雌激素敏感的人类乳腺癌细胞系 (MCF-7和T47D-KBluc) 的影响.
为了确定对细胞活力,增殖,基因表达和氧化应激的影响.

主要方法:

暴露MCF-7和T47D-KBluc细胞的杀菌剂 (boscalid,cyprodinil,iprodione) 有或没有tamoxifen和17β-estradiol.
检测细胞活力,增殖,记者基因表达,ROS含量,细胞膜功能和抗氧化酶基因表达.
使用了对17β-雌二醇有反应的细胞系,以进行准确的评估.

主要成果:

所有测试的杀菌剂都显著增加了细胞活力和增殖.
对所有杀菌剂,以剂量依赖的方式观察到雌激素活性.
杀菌剂通过增加ROS产量和抑制抗氧化剂防御来诱导氧化应激,促进癌细胞的增殖.

结论:

研究的杀菌剂 (博斯卡利德,cyprodinil,iprodione) 具有内分泌干扰的特性.
这些化合物可以通过雌激素和氧化应激途径促进不受控制的癌细胞增殖.
应该尽量减少对这些杀菌剂的饮食暴露,以减少健康风险.

关键词:

这些EDC化合物是EDC化合物.博斯卡利德 (Boscalid) 是一个波斯卡利德.乳腺癌乳腺癌乳腺癌这种药物是cyprodinil.艾普罗迪 (iprodione) 是一种

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