益生菌封装:珠子设计在体外消化过程中提高了细菌的性能
Yesica Vanesa Rojas-Muñoz1, Patricio Román Santagapita2, María Ximena Quintanilla-Carvajal1,3
1Maestría en Diseño y Gestión de Procesos, Facultad de Ingeniería, Campus Universitario del Puente del Común, Universidad de La Sabana, Chía 250001, Colombia.
Polymers
|November 14, 2023
概括
优化墙壁材料用于 Lactobacillus fermentum K73 封装使用离子热凝显著改善了在加工和模拟胃肠道条件期间益生菌的生存率.
科学领域:
- 食品科学与技术 食品科学与技术
- 微生物学 微生物学
- 生物技术是生物技术.
背景情况:
- 生物活性囊的稳定性和释放性在很大程度上取决于墙壁材料组成.
- 乳杆菌发酵K73是一种乳酸细菌,具有潜在的降胆固醇益处.
- 离子热是一种封装益生菌的关键技术.
研究的目的:
- 评估墙壁材料在电离子凝过程中对Lactobacillus fermentum K73活力的影响.
- 在模拟的胃肠道条件下优化封装参数,以提高益生菌的存活率.
- 为了确定封装L.L.的低胆固醇血清益生菌潜力. 发酵物 K73.3. 发酵物 K73.
主要方法:
- 使用响应表面方法来优化墙壁材料组成 (凝,糖乳糖,藻酸盐).
- 用离子热进行封装,然后对颗粒大小和产量进行表征.
- INFOGEST模型模拟了体外胃肠道条件,以评估益生菌的存活率.
主要成果:
- 没有凝的最佳配方,糖乳清与甲基酸盐的比率为0.39/0.61/v,产生了95 ± 3%的封装.
- 被封装的L.L. 发酵K73在口腔,胃和肠道阶段表现出最小的活力损失 (0.32-1.53 log10 CFU/mL).
- SEM和ATR-FTIR技术为益生菌珠子提供了特征.
结论:
- 优化的配方显著增强了L. 在封装和模拟消化过程中,K73的生存率.
- 这项研究提供了一种强大的方法,用于生产具有降胆固醇潜力的稳定,可行的益生菌囊.
- 这些发现支持使用具有特定墙壁材料的离子转化凝来改善益生菌的传递.
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