树成草提取物对卵巢切除糖尿病小鼠外周神经病的缓解作用
Chih-Yuan Ko1,2,3, Chung-Hsin Wu4, Thi Kim Ngan Nguyen5
1Department of Clinical Nutrition, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.
Plants (Basel, Switzerland)
|November 14, 2023
概括
菲克斯福尔莫萨纳提取物 (FFE) 可以治疗小鼠的糖尿病外围神经病变 (DPN). 在卵巢切除的糖尿病小鼠中,FFE减少了疼痛和神经损伤,这表明DPN的治疗潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病与炎症和血糖升高有关.
- 花 (Ficus formosana) 具有抗炎和降血糖的特性.
- 在糖尿病外围神经病 (DPN) 上,Ficus formosana对糖尿病外围神经病 (DPN) 的影响尚不清楚.
研究的目的:
- 在小鼠模型中研究Ficus formosana提取物 (FFE) 对DPN的治疗潜力.
- 评估FFE对卵巢切除糖尿病小鼠疼痛反应和神经完整性的影响.
主要方法:
- 经过卵巢切除的C57BL/6J小鼠使用高脂肪饮食和链毒素诱导了2型糖尿病.
- 小鼠每天接受FFE (20或200毫克/体重) 的口服,持续6周.
- 疼痛敏感性是使用弗雷丝丝和热性过敏症测试来评估的.
- 分析了皮内和坐骨神经部分,以及炎症和疼痛标志物的mRNA表达.
主要成果:
- 施用FFE显著缓解了脚过敏和C纤维异常.
- FFE治疗减少了关键炎症和疼痛介导体 (IL-1β,IL-6,IFN-γ,COX-2,Nav1.8) 的mRNA表达.
- FFE 显示了对 DPN 症状的剂量依赖改善.
结论:
- 菲克斯·福尔莫萨纳提取物在改善卵巢切除的糖尿病小鼠中的DPN方面表现有前途.
- 通过抑制氧化损伤和炎症,FFE可能会发挥其神经保护作用.
- 需要进一步的研究来探索FFE作为DPN的潜在治疗剂.
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