地中海饮食:对超重或肥胖个体的胰岛素抵抗和分泌的影响
Claudia Vetrani1,2, Ludovica Verde2,3, Annamaria Colao2,4,5
1Dipartimento di Scienze Umanistiche, Università Telematica Pegaso, Centro Direzionale, Via Porzio, Isola F2, 80143 Naples, Italy.
Nutrients
|November 14, 2023
概括
高地中海饮食 (MD) 的坚持,特别是鱼类消费,与超重/肥胖个体的胰岛素抵抗性 (IR) 降低和胰岛素敏感性 (IS) 提高有关. 这种饮食模式对葡萄糖代谢标志物产生积极影响.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 坚持高地中海饮食 (MD) 与降低2型糖尿病风险有关.
- 药物成分对胰岛素抵抗 (IR) 和胰岛素分泌 (IS) 的具体影响需要进一步研究,特别是在超重/肥胖人群中.
研究的目的:
- 研究地中海饮食 (MD) 坚持与胰岛素抵抗 (IR),胰岛素敏感性 (IS) 和胰岛素分泌 (IS) 标志物之间的关系.
- 探索特定的MD食品对超重/肥胖个体这些代谢参数的影响.
主要方法:
- 一项涉及62名超重/肥胖个体 (7M/55F) 的横截面研究 (平均BMI 35.8 ± 6.7 kg/m2).
- 口服葡萄糖耐受性测试 (OGTT) 用于测量血葡萄糖和胰岛素.
- 计算胰岛素耐药性 (HOMA-IR) 和胰岛素敏感性 (ISI) 的验证指数;通过预定问卷评估MD坚持.
- 用于分析OGTT衍生指数,MD坚持和特定MD食品之间的关联的二变相关性.
主要成果:
- 与其他组相比,高MD坚持组的HOMA-IR显着较低 (p=0.022) 和高ISI (p=0.033).
- 高的MD坚持与HOMA-IR (r=-0.400; p=0.004) 反相关,与ISI (r=0.296; p=0.039) 直接相关.
- 鱼类消费,一个关键的MD组件,与ISI正相关 (r=0.394;p=0.005) 和与HOMA-IR (r=-0.327;p=0.019) 和HOMA-β (r=-0.489;p<0.001) 负相关.
结论:
- 对地中海饮食的高度坚持与过重/肥胖个体的胰岛素抵抗性降低和胰岛素敏感性改善有关.
- 鱼类的消费是MD的重要组成部分,在这些有益的代谢作用中起着至关重要的作用,特别是在减轻胰岛素抵抗方面.
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