相关实验视频

Updated: Jul 11, 2025

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

基于免疫调节和肠道微生物群的不同分子量的炭甲基帕奇马兰的抗瘤活性

Yalin Zhao¹, Xi Feng², Lijia Zhang¹

¹College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

|November 14, 2023

概括

修饰的碳甲基帕奇马兰 (CMP) 衍生物显示出显著的抗瘤活性. 该研究强调了它们作为免疫调节剂的潜力,特别是HTEC-24,用于开发新型癌症药物.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
免疫学免疫学免疫学

背景情况:

炭甲基帕奇马兰 (CMP) 是一种具有潜在生物活性的多糖体.
调查CMP的修改可以导致增强的治疗特性.
了解结构-活性关系对于药物开发至关重要.

研究的目的:

为了合成和表征改性碳甲基帕奇马兰 (CMP) 衍生物.
评估这些CMP衍生物的体内抗瘤活性.
探索免疫调节效应和对肠道微生物群的影响.

主要方法:

使用高温和细胞酶水解来修改CMP.
分析了分子重量,粘度和颗粒大小.
在动物模型中评估了体内抗瘤活性.
研究了免疫调节效应 (IFN-γ,IL2) 和肠道微生物群.

主要成果:

与原生CMP相比,修改后的CMP (HTCMP,HTEC-24,HTEC-48) 显示分子重量减少.
所有CMP衍生品都表现出抗瘤能力,HTEC-24显示出最高的疗效.
CMPs通过增加IFN-γ和IL2分泌而显示出免疫调节作用.
抗瘤效应与瘤携带小鼠肠道微生物群的调节有关.

结论:

修改后的CMP,特别是HTEC-24,具有显著的抗瘤和免疫调节特性.
这些发现为开发基于CMP的抗瘤药物提供了基础.
这项研究强调了CMP衍生物在调节免疫系统和肠道微生物群中的作用,用于癌症治疗.

关键词:

抗瘤活动抗瘤活动炭甲基帕奇马兰是什么我们的肠道微生物群.分子重量的分子质量.结构性特征的结构性特征.

更多相关视频

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...