肠道微生物群,衍生代谢物和阻塞性睡眠呼吸暂停之间的因果关系调查:双向门德尔随机化研究
Weiheng Yan1, Miaomiao Jiang2, Wen Hu3
1Department of Otolaryngology, Head and Neck Surgery, Children's Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China.
Nutrients
|November 14, 2023
概括
这项研究使用了门德尔的随机化来调查肠道微生物和阻塞性睡眠呼吸暂停 (OSA) 中的代谢物之间的因果关系. 某些肠道细菌和代谢物显著影响OSA风险,提供新的治疗点.
科学领域:
- 微生物组研究 微生物组研究
- 遗传学 遗传学 是一个
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与肠道微生物群和代谢物有关,但因果关系尚不清楚.
- 了解这些联系对于开发新的OSA治疗策略至关重要.
研究的目的:
- 从遗传学上确定肠道微生物群和代谢物对阻塞性睡眠呼吸暂停 (OSA) 的因果影响.
- 探索肠道微生物群和与OSA相关的代谢物之间的因果独立性.
主要方法:
- 使用双样本的门德尔随机化 (MR) 分析对196个肠道微生物群和83个代谢物.
- 使用逆方差加权 (IVW),MR-Egger和加权中位数 (WM) 方法进行因果关系评估.
- 进行了多变量MR (MVMR) 和灵敏度分析 (Cochran's Q,MR Egger拦截,MR Steiger) 的稳定性.
主要成果:
- 确定了特定的肠道细菌 (例如, *Ruminococcaceae*, *Subdoligranulum*, *Coprococcus2*, *Eggerthella*, *Eubacterium*) 对OSA风险产生因果作用.
- 发现3 - 脱卡尼丁,埃皮安德罗斯特硫酸盐和白是OSA潜在的独立风险因素.
- 反向MR分析表明,OSA与六种微生物群类之间存在暗示性关联.
结论:
- 提供了肠道微生物群和代谢物在OSA发展中的因果作用的证据.
- 突出了潜在的有益或有害影响,为微生物介导的OSA机制提供了新的见解.
- 建议通过肠道微生物组调节来预防和治疗OSA的新目标.
相关概念视频
Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Microbiota of the Respiratory Tract
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


