在经过胃切除术的胃癌患者中,为免疫功能和肠粘膜屏障提供外科肠道免疫营养支持:一项前性随机对照研究
Mingwei Ma1, Zicheng Zheng1, Ziyang Zeng1
1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
外科手术期间的肠道免疫营养显著改善了激进胃切除术患者的免疫和肠道屏障功能. 这导致并发症减少,恢复速度更快.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 临床营养学 临床营养学
背景情况:
- 激进胃切除术患者在手术后经常经历免疫和肠道屏障功能受损.
- 术后免疫营养在减轻这些影响方面的作用尚未完全理解.
研究的目的:
- 评估肠道免疫营养对术后免疫和肠粘膜屏障功能的影响.
- 为了比较接受肠道免疫营养的患者和激进胃切除术后的对照组之间的结果.
主要方法:
- 一项前性随机试验,涉及65名接受激进胃切除术的患者.
- 患者被分配到肠道免疫营养组或对照组.
- 评估了肠道屏障功能的术后标志物,免疫状态,炎症和营养指标.
主要成果:
- 免疫营养组在术后第3天和第7天显示出明显较低的二胺氧化酶,D-乳酸和内毒素水平.
- 接受免疫营养的患者经历了更早的浮和排便,以及较少的术后并发症.
- 在免疫营养组中观察到改善的免疫标志物 (较低的WBC,NLR;较高的CD4+T,CD8+T) 和白蛋白水平.
结论:
- 外科手术期间的肠道免疫营养有效地增强了胃切除术后的免疫和肠粘膜屏障功能.
- 这种营养支持减少了炎症,降低了并发症率,并促进了患者的加速恢复.
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