肠道微生物群与乳腺癌之间的关联:饮食作为潜在的调节因素
Duygu Altinok Dindar1, Brie Chun2, Amy Palma3
1Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Nutrients
|November 14, 2023
概括
肠道微生物组,特别是像Acidaminococcus和Hungatella这样的特定细菌,在乳腺癌 (BCa) 患者中不同. 这些微生物变化与饮食有关,这表明BCa风险评估的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 乳腺癌 (BCa) 有已知的风险因素,但肠道微生物组的作用正在调查中.
- 饮食和生活方式已被确定为BCa风险的贡献者.
- 了解肠道微生物群的影响对于全面的BCa风险评估至关重要.
研究的目的:
- 探索肠道微生物组组成,饮食习惯和乳腺癌 (BCa) 风险之间的关联.
- 在BCa患者中识别特定的微生物特征.
- 在BCa.的背景下,研究肠道细菌和饮食模式之间的联系.
主要方法:
- 一项病例控制研究纳入了新诊断的BCa患者和无癌症的对照.
- 使用国家癌症研究所饮食历史问卷 (DHQ) 评估饮食习惯.
- 用16S rRNA amplicon测序分析了肠道微生物组合,评估了多样性和特定属的丰富性.
主要成果:
- 与对照组相比,BCa患者的肠道微生物多样性减少.
- 在BCa患者中,特定的属 (Acidaminococcus, Tyzzerella, Hungatella) 被丰富.
- 这些丰富的属性显示出与蔬菜,乳制品和全果等饮食成分的显著关联.
结论:
- 肠道微生物组的改变与乳腺癌 (BCa) 有关.
- 特定的肠道微生物基因与饮食模式相关,这表明了复杂的相互作用.
- 肠道微生物组有可能成为BCa风险评估的新生物标志物的来源.
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