热量限制对接受新辅助化疗治疗的乳腺癌患者的影响:一项前性病例控制研究
Isabella Castellano1, Francesco Gallo2, Paola Durelli2
1Pathology Unit, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, 10126 Turin, Italy.
Nutrients
|November 14, 2023
概括
热量限制 (CR) 与新辅助化疗 (NACT) 结合,显著改善了乳腺癌患者的瘤大小和淋巴结状况. 这种饮食干预表明了安全性和有效性,为癌症治疗提供了有希望的方法.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 癌症治疗 癌症治疗
背景情况:
- 热量限制 (CR) 影响了与癌症相关的代谢和激素因素.
- 新出现的证据表明,CR对乳腺癌 (BC) 的全身疗法反应产生积极影响.
- 对于BC的新辅助化疗 (NACT) 中CR的作用,数据有限.
研究的目的:
- 评估CR对接受NACT的乳腺癌患者的影响.
- 评估CR在该患者群体中的营养有效性和安全性.
主要方法:
- 在两个乳腺单位进行前性病例对照研究.
- CR组 (39名患者):30%的热量减少,在化疗日增加到50%.
- 对照组 (60名患者):NACT与一般WCRF饮食建议.
主要成果:
- 与单独使用NACT相比,CR + NACT显示了瘤大小 (OR 2.94) 和淋巴结状况 (OR 3.22) 的显著改善.
- 经过对生物参数进行调整后,统计学意义保持不变.
- 人类测量和生物化学分析证实了干预的有效性和安全性.
结论:
- 与对照组相比,在NACT期间遵守CR导致乳腺和淋巴结的治疗反应优越.
- 与NACT相结合的CR饮食被很好地容忍和安全.
- 对于接受NACT的乳腺癌患者来说,CR是一种潜在的有益的辅助疗法.
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