来自微生物群的细胞外囊泡促进哺乳大鼠的免疫力和肠道成熟
Sergio Martínez-Ruiz1,2,3, Laura Sáez-Fuertes1,4, Sergi Casanova-Crespo1,4
1Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.
Nutrients
|November 14, 2023
概括
每天给年轻的小鼠服用肠道微生物细胞外囊泡 (EVs),增强了免疫反应和肠道成熟. 这种后生物策略表明,它有望刺激早期免疫力和肠道发育.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 微生物群与宿主之间的通信依赖于像细胞外囊泡 (EVs) 这样的分泌因素.
- 在疾病模型中研究了肠道微生物EV,但它们在体内对生命早期发育的影响尚不清楚.
- 了解EV在生命早期的作用对于免疫和肠道成熟至关重要.
研究的目的:
- 调查益生菌和开始性大肠杆菌EVs对哺乳大鼠的影响.
- 评估每日EV给药对生命前16天免疫和肠道发育的影响.
主要方法:
- 每天向健康的哺乳大鼠注射益生菌和开始性大肠杆菌菌株的EV.
- 在第8天和第16天评估肠道和全身变量,包括生长,免疫力,屏障功能和肠道结构.
- 对血免疫球蛋白水平,脏免疫细胞种群和肠道基因表达的分析.
主要成果:
- 经过EV治疗的动物在第16天呈现出血IgG,IgA和IgM水平的增加.
- 在接受EV治疗的老鼠的脏中观察到较高比例的T细胞 (Tc),自然杀手细胞 (NK) 和NKT细胞.
- EVs增加了小肠小的面积,并促进了抗炎,屏障保护性基因表达特征.
结论:
- 每天服用益生菌/微生物群EVs可以安全地刺激生命早期的免疫力和肠道成熟.
- EVs代表了一种有前途的后生物策略,用于增强婴儿肠道健康和免疫发育.
- 这项研究强调了微生物EV作为儿科治疗剂的潜力.
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