萨科佩尼亚预测了晚期慢性病中的心血管疾病和相关风险
Yingli Xuan1, Shiqing Pang, Weizhen Xie
1Department of Nephrology, Baoshan Branch of Renji Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China.
Medicine
|November 14, 2023
概括
软骨症或肌肉损失在晚期慢性病 (CKD) 中很常见,并预测动脉样硬化心血管疾病 (ASCVD) 风险. 这种情况与CKD患者的炎症和营养不良有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 慢性病 (CKD) 是心血管疾病 (CVD) 的已知危险因素.
- 标志着肌肉质量和力量的损失的萨科佩尼亚是CKD的新兴风险因素.
- 萨科佩尼亚对慢性病患者心血管疾病的预测作用尚不清楚,特别是在晚期.
研究的目的:
- 为了确定患有第三阶段或更高CKD的患者中肉类的患病率.
- 在这个人群中,调查沙科佩尼亚和心血管疾病风险之间的关联.
- 为了确定与慢性病患者的肉症相关的临床和实验室因素.
主要方法:
- 分析了101名患有CKD阶段≥3的患者队列.
- 患者被分为三种类型的sarcopenia (n=19) 和非sarcopenia (n=82) 组.
- 收集的数据包括人口统计,实验室测试 (白蛋白,CRP),心脏外脂肪组织 (EAT) 厚度和ASCVD风险得分.
主要成果:
- 在晚期CKD患者中,肉类的患病率为19%.
- 与非sarcopenia组相比,sarcopenia组的患者年龄较大,疾病持续时间较长,白蛋白较低,CRP较高,EAT厚度增加.
- ASCVD风险得分与炎症,营养状况,BMI和 Sarcopenia 组中的 CKD 持续时间正相关.
结论:
- 患有晚期CKD的患者患有高患病率的肉症.
- 慢性脏病中的肉症与炎症增加,营养不良和更高的ASCVD风险有关.
- 萨科佩尼亚是慢性脏病患者心血管风险的重要预测因素.
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