母亲维生素D缺乏与分娩后出血和子宫缩之间的关联
Anna Sörsjö Stevenazzi1, Sofia Pihl2, Marie Blomberg2
1Department of Obstetrics and Gynecology, Ryhov County Hospital, Jönköping, Sweden.
Acta obstetricia et gynecologica Scandinavica
|November 14, 2023
概括
维生素D缺乏似乎不会增加产后出血或产后无动性出血的风险. 这项研究发现维生素D水平与分娩后出血之间没有关联.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 产后出血 (PPH) 是全球领先的孕产妇死亡原因.
- 虽然PPH的风险因素已知,但预易性因素需要进一步调查.
- 维生素D缺乏与剖腹产有关,可能是由于维生素D对肌肉功能的影响.
研究的目的:
- 调查维生素D状况与产后出血风险之间的关联,包括心脏性PPH.
- 确定维生素D缺乏是否是PPH的诱导因素.
主要方法:
- 在瑞典对1367名女性进行了回顾性翻译研究.
- 在分娩时测量血清25-氧化维生素D度.
- 定义的维生素D不足 (<50nmol/L) 和缺乏 (<25nmol/L).
- 在产后2小时内评估PPH (≥500毫升),严重PPH (≥1000毫升) 和无毒PPH.
- 使用后勤回归来计算调整的赔率比率.
主要成果:
- 57%的女性患有维生素D不足或缺乏.
- PPH和严重的PPH分别发生在31.3%和6.4%的女性中.
- 性PPH影响了研究人口的21%.
- 没有发现维生素D不足/缺乏与PPH或无氧PPH之间有统计学意义的关联.
结论:
- 出生时的维生素D状况不是整体产后出血的预测因素.
- 在这个队列中,维生素D水平与心脏性产后出血风险增加无关.
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