前环状皮质中的星细胞和L-乳酸盐调节了模式记忆和神经元线粒体生物发生
Mastura Akter1,2, Mahadi Hasan1,2, Aruna Surendran Ramkrishnan1,2
1Department of Neuroscience, City University of Hong Kong, Hong Kong SAR, China.
eLife
|November 14, 2023
概括
在大脑的ACC中激活天体细胞Gi信号会通过减少L-乳酸盐来损害记忆和学习. 补充L-乳酸盐可以恢复这些认知功能,突出其关键作用.
科学领域:
- 神经科学是一个神经科学.
- 细胞神经科学 细胞神经科学
- 认知神经科学 认知神经科学
背景情况:
- 来自天体细胞的L-乳酸盐支持突触可塑性和认知功能.
- 在前带皮质 (ACC) 中的星系Gi信号传递对L-乳酸盐水平和模式记忆的作用仍然不清楚.
研究的目的:
- 研究ACC中的星细胞Gi信号如何影响L-乳酸盐水平,模式记忆和相关的认知功能.
- 阐明连接天体细胞Gi信号,L-乳酸盐和记忆形成的潜在机制.
主要方法:
- 在老鼠的ACC中,化学基因对星系Gi信号的操纵.
- 行为范式评估配对协同 (PA) 学习,模式形成和记忆检索.
- 测量L-乳酸盐水平和评估神经元线粒体生物发生.
主要成果:
- 在ACC中激活星细胞Gi通路显著损害了PA学习,模式形成和记忆检索.
- 这些损伤与ACC中的L-乳酸盐水平降低有关,这些水平通过外源L-乳酸盐给药来挽救.
- 图表记忆障碍与神经元线粒体生物发生减少相关,依赖于L-乳酸盐,单碳酸盐转运体2 (MCT2) 和NMDA受体活性.
结论:
- 在ACC中的星细胞Gi信号负面调节L-乳酸盐水平,影响图表记忆和认知功能.
- L-乳酸盐在神经元线粒体生物发生和记忆中发挥着关键作用,由MCT2和NMDA受体介导.
- 这项研究揭示了一种新的信号通路,涉及大脑记忆过程中的星体细胞,L-乳酸盐和线粒体功能.
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